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KMID : 0351619660070020153
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Kyungpook Medical Journal
1966 Volume.7 No. 2 p.153 ~ p.160
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Studies on the Effect of the Colloidal Osmotic Pressure on the Plasma and Liver Protein Synthesis in Perfused Liver.
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Abstract
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This paper is concerned with studies on the effect of colloidal osmotic pressure on the plasma and Iiver protein synthesis in perfused livers.
Colloidal osmotic pressure of the blood perfusate was altered by eliminating the plasma protein or adding of polyvinylpyrrolidone or excess serum albumin. When the plasma of blood perfusate was substituted with Ringer-Locke solution, the rate of synthesis of plasma protein showed considerable increase, but as to liver protein the rate was conversely decreased as compared with normal blood perfusate. The difference in protein synthesis shown when plasma was substitutes with Ringer-Locke solution was not revealed in the perfused liver with the perfusate of high colloidal osmotic pressure induced by addition of 6% P.V. P. in the Ringer-Locke solution. The rates of synthesis of plasma and liver protein in 6% P.V. P. Ringer-Locke solution were almost same as in albumin added plasma (added 3g. of albumin per 100ml. of plasma) except in albumin synthesis which somewhat lower in albumin added plasma.
After 4 hours´ perfusion of each liver in Ringer-Locke solution and in 6% P.V. P. Ringer-Locke solution, the livers were exchanged with one another and continued with the perfusion for 4 hours. The results also showed that, in Ringer-Locke solution, the rate of synthesis of plasma protein was higher than in P.V. P. Ringer-Locke solution before and after the perfusate was changed, even though for the first one hour after transfer the rates of synthesis in both livers were a little suspended.
All the above results appear to the that in low colloidal osmotic pressure the liberation of albumin from liver tissue would be increased.
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